Fig. 2

Genotyping of ICD-related genes. A Enriched ontology clusters of ICD genes analyzed by Metascape, colored by cluster-ID. B Heatmap shows 34 ICD gene expression differences among tumor and peritumor samples in TCGA. C Total of 374 HCC patients was identified into two clusters according to the consensus clustering matrix (k = 2). D Validation of HSP90AA1 expression in clinical tumor tissues by representative images of hepatocellular carcinoma and IHC of tumor and peritumor tissue. E Heatmap shows ICD-related gene expression differences between ICD-low and ICD-high clusters in TCGA. F Kaplan-Meier survival curves for the two clusters (P < 0.001). G, H Comparison of the mutation landscape between ICD-low and ICD-high clusters