Table 6 Survival outcome of patients < 1 year (A) and > 1 year (B) from diagnosis to systemic treatment according to the first and second-line treatments and sequencing after age, sex, and CCI matching

A. Less than 1 year

Variables

Number (%)

HR

95% CI

p

Overall survival: first-line treatment

 SUN

714 (48.8)

Ref

 PAZ

749 (51.2)

1.172

1.042–1.319

0.0081

Overall survival: second-line treatment

 CAB

118 (8.1)

Ref

 AXI

355 (24.3)

0.764

0.573–1.020

0.0680

 EVE

990 (67.6)

1.337

1.035–1.727

0.0261

Overall survival: sequencing

 PAZ–AXI

226 (15.5)

Ref

 PAZ–CAB

73 (5.0)

1.335

0.929–1.919

0.1187

 PAZ–EVE

450 (30.7)

1.873

1.514–2.317

 < 0.0001

 SUN–AXI

129 (8.8)

0.829

0.609–1.130

0.2352

 SUN–CAB

45 (3.1)

1.057

0.674–1.658

0.8099

 SUN–EVE

540 (36.9)

1.465

1.189–1.805

0.0003

B. Over than 1 year

Variables

Number (%)

HR

95% CI

p

Overall survival: first-line treatment

 SUN

500 (51.8)

Ref

 PAZ

465 (48.2)

1.120

0.951–1.317

0.1737

Overall survival: second-line treatment

 CAB

91 (9.4)

Ref

 AXI

250 (25.9)

0.610

0.394–0.944

0.0264

 EVE

624 (64.7)

1.841

1.281–2.644

0.0010

Overall survival: sequencing

 PAZ–AXI

168 (17.4)

Ref

 PAZ–CAB

58 (6.0)

1.810

1.053–3.111

0.0318

 PAZ–EVE

239 (24.8)

3.577

2.527–5.064

 < 0.0001

 SUN–AXI

82 (8.5)

0.846

0.492–1.454

0.5446

 SUN–CAB

33 (3.4)

1.207

0.616–2.364

0.5835

 SUN–EVE

385 (39.9)

2.510

1.791–3.518

 < 0.0001