Table 5 Survival outcome according to the first and second-line treatments and sequencing after age, sex, and CCI matching

Overall survival: first-line treatment

 SUN

1,214 (50)

Ref

29

 PAZ

1,214 (50)

1.167

1.061–1.283

0.0015

21

Overall survival: second-line treatment

 CAB

209 (8.6)

Ref

19

 AXI

605 (24.9)

0.735

0.578–0.934

0.0118

24

 EVE

1,614 (66.5)

1.544

1.253–1.903

 < 0.0001

25

Overall survival: sequencing

 PAZ–AXI

394 (16.2)

Ref

23

 PAZ–CAB

131 (5.4)

1.45

1.073–1.958

0.0155

18

 PAZ–EVE

689 (28.4)

2.414

2.015–2.894

 < 0.0001

21

 SUN–AXI

211 (8.7)

0.876

0.67–1.145

0.3312

26

 SUN–CAB

78 (3.2)

1.089

0.749–1.582

0.655

23

 SUN–EVE

925 (38.1)

1.769

1.482–2.111

 < 0.0001

31