Table 4 Clinical characteristics according to the first- and second-line treatments after age, sex, and CCI matching
Variables | Total (nā=ā2,428) | First-line treatment | Second-line treatment | |||||
|---|---|---|---|---|---|---|---|---|
| Ā | Ā | SUN (1,214, 50%) | PAZ (1,214, 50%) | p | EVE (1,614, 66.5%) | AXI (605, 24.9%) | CAB (209, 8.6%) | p |
Age, mean (SD) | 61.71 (10.52) | 61.43 (10.23) | 61.99 (10.8) | 0.1844 | 61.58 (10.47) | 62.11 (10.88) | 61.52 (9.84) | 0.5513 |
Age group | Ā | Ā | Ā | 1.0 | Ā | Ā | Ā | 0.1553 |
āā<ā55 | 574 (23.6) | 287 (23.6) | 287 (23.6) | Ā | 388 (24.0) | 141 (23.3) | 45 (21.5) | Ā |
ā55ā59 | 370 (15.3) | 185 (15.3) | 185 (15.3) | Ā | 243 (15.1) | 91 (15.0) | 36 (17.2) | Ā |
ā60ā64 | 484 (19.9) | 242 (19.9) | 242 (19.9) | Ā | 302 (18.7) | 127 (21.0) | 55 (26.3) | Ā |
ā65ā69 | 430 (17.7) | 215 (17.7) | 215 (17.7) | Ā | 302 (18.7) | 95 (15.7) | 33 (15.8) | Ā |
āāā„ā70 | 570 (23.5) | 285 (23.5) | 285 (23.5) | Ā | 379 (23.5) | 151 (25.0) | 40 (19.2) | Ā |
Sex (%) | Ā | Ā | Ā | 1.0 | Ā | Ā | Ā | 0.1443 |
āMale | 1,864 (76.8) | 932 (76.8) | 932 (76.8) | Ā | 1,220 (75.6) | 477 (78.8) | 167 (79.9) | Ā |
āFemale | 564 (23.2) | 282 (23.2) | 282 (23.2) | Ā | 394 (24.4) | 128 (21.2) | 42 (20.1) | Ā |
Income level (%) | Ā | Ā | Ā | 0.3779 | Ā | Ā | Ā | 0.0653 |
ā0%ā20% (lowest) | 485 (20.0) | 226 (18.6) | 259 (21.3) | Ā | 307 (19.0) | 126 (20.8) | 52 (24.9) | Ā |
ā20%ā40% | 333 (13.7) | 161 (13.3) | 172 (14.2) | Ā | 228 (14.2) | 83 (13.7) | 22 (10.5) | Ā |
ā40%ā60% | 419 (17.2) | 216 (17.8) | 203 (16.7) | Ā | 294 (18.2) | 90 (14.9) | 35 (16.8) | Ā |
ā60%ā80% | 529 (21.8) | 266 (21.9) | 263 (21.7) | Ā | 338 (20.9) | 153 (25.3) | 38 (18.2) | Ā |
ā80%ā100% | 662 (27.3) | 345 (28.4) | 317 (26.1) | Ā | 447 (27.7) | 153 (25.3) | 62 (29.6) | Ā |
Residence (%) | Ā | Ā | Ā | 0.0959 | Ā | Ā | Ā | 0.0224 |
āmetropolitan | 1,173 (48.3) | 607 (50) | 566 (46.6) | Ā | 807 (50) | 263 (43.5) | 103 (49.3) | Ā |
āOther region | 1,255 (51.7) | 607 (50) | 648 (53.4) | Ā | 807 (50) | 342 (56.5) | 106 (50.7) | Ā |
CCI (%) | Ā | Ā | Ā | 1.0 | Ā | Ā | Ā | 0.9854 |
ā0 | 786 (32.4) | 393 (32.4) | 393 (32.4) | Ā | 528 (32.7) | 193 (31.9) | 65 (31.1) | Ā |
ā1ā2 | 1,212 (49.9) | 606 (49.9) | 606 (49.9) | Ā | 800 (49.6) | 306 (50.6) | 106 (50.7) | Ā |
āāā„ā3 | 430 (17.7) | 215 (17.7) | 215 (17.7) | Ā | 286 (17.7) | 106 (17.5) | 38 (18.2) | Ā |
Department (%) | ||||||||
āUrology | 1,060 (43.6) | 650 (53.5) | 410 (33.7) | ā<ā0.0001 | 744 (46.1) | 246 (40.7) | 70 (33.5) | 0.0004 |
āInternal | 1,330 (54.8) | 551 (45.4) | 779 (64.2) | Ā | 848 (52.5) | 344 (56.9) | 138 (66.0) | Ā |
āOthers | 38 (1.6) | 13 (1.1) | 25 (2.1) | Ā | 22 (1.4) | 15 (2.4) | 1 (0.5) | Ā |
Time from initial diagnosis to systemic treatment | Ā | Ā | Ā | 0.1467 | Ā | Ā | Ā | 0.2623 |
āā<ā1Ā year | 1,463 (60.3) | 714 (58.8) | 749 (61.7) | Ā | 990 (61.3) | 355 (58.7) | 118 (56.5) | Ā |
āāā„ā1Ā year | 965 (39.7) | 500 (41.2) | 465 (38.3) | Ā | 624 (38.7) | 250 (41.3) | 91 (43.5) | Ā |