Table 3 Survival outcome according to the first- and second-line treatments and sequencing

Overall survival: first-line treatment

 SUN

1,787 (55.0)

Ref

28

 PAZ

1,460 (45.0)

1.209

1.113–1.315

 < 0.0001

21

Overall survival: second-line treatment

 CAB

276 (8.5)

Ref

21

 AXI

773 (23.8)

0.807

0.652–1.0

0.0495

24

 EVE

2,198 (67.7)

1.658

1.377–1.997

 < 0.0001

26

Overall survival: sequencing

 PAZ–AXI

473 (14.6)

1.088

0.798–1.484

0.5946

22

 PAZ–CAB

152 (4.7)

1.383

0.960–1.991

0.0815

19.5

 PAZ–EVE

835 (25.7)

2.423

1.823–3.219

 < 0.0001

21

 SUN–AXI

300 (9.2)

0.795

0.569–1.110

0.1773

26

 SUN–CAB

124 (3.8)

Ref

23

 SUN–EVE

1,363 (42.0)

1.760

1.330–2.329

 < 0.0001

30