Table 3 Scoring HOFs

1

GPS [41, 53]; mGPS [8, 39]; MGPS [93]

Glasgow prognostic score [41, 53]; modified Glasgow prognostic score [8, 93]

Alb score + CRP score

Assign score = 1 to each of the following: Alb < 3.5 g/dL, CRP > 10 mg/L [41, 53]; or Alb < 35 g/L, CRP > 8  mg/L [8, 39]; or Alb < 35 g/L, CRP ≥ 10 mg/L [93]

2

ACBS [8, 99]

The Aarhus composite 5 score [8, 99]

Alb score + CRP score + HGB score + Lymph score + Neu score

Assign score = 1 to each of the following: Alb ≤ 36 g/L, CRP ≥ 8 mg/L, Neu > 7 × 10⁹/L, Lymph ≤ 1.3 × 10⁹/L, and HGB < 7.3 (women) / 8.3 (men) mmol/L [99]; or Lymph < 3.5 × 10⁹/L [8]

3

CNG [8, 99]

the combination of NLR and GPS

Alb score + CRP score + NLR score

Assign score = 1 to each of the following: Alb < 35 g/L, CRP > 8 mmol/L, NLR > 2 [8]; or NLR > 1.9 [99]

4

ALB-dNLR [100, 101]

Alb score + dNLR score

Assign score = 1 to each of the following: Alb ≤ 39.6 g/L, dNLR > 1.365 [100] or Alb ≤ 40 g/L, dNLR > 1.77 [101]

5

SIS [53]; mSIS [15]

The systemic inflammation score [53]; modified SIS [15]

Alb score + LMR score

Assign score = 1 to each of the following: Alb < 39.75 g/L, LMR < 3.8 [53]; or Alb < 40 g/L, LMR < 3.4 [15]

6

 A.L.A.N. score [102]

Alb score + LMR score + Neu score + NLR score

Assign score = 1 to each of the following: Alb < 35 g/L, LMR < 2.1, Neu > 7 × 10⁹/L, NLR > 3

7

INA [13]

Instant nutritional assessment

Alb score + Lymph score

Assign score = 1 for Lymph < 1.3 × 10⁹/L, score = 2 for Alb < 35 g/L

8

CONUT score [13]

the CONtrolling NUTritional status

Alb score + Lymph score + TChol score

Assign scores for Alb (0 = ≥ 3.5 g/dl; 2 = 3.0–3.49 g/dL; 4 = 2.50–2.99 g/dL; 6 = < 2.50 g/dL), Lymph (0 = ≥ 1.6 × 10⁹ G/L; 1 = 1.20–1.59 G/L; 2 = 0.80–1.19 G/L; 3 = < 0.8 G/L), TChol (0 = ≥ 180 mg/dL; 1 = 140–179 mg/dL; 2 = 100–139 mg/dL; 3 = < 100 mg/dL)

9

ANPG [103]

Alb score + Neu score

Assign score = 1 to each of the following: Alb < 35 g/L, Neu > 2 or < 7

10

Alb-NLR

Albumin-NLR [104]

Alb score + NLR score

Assign score = 1 to each of the following: Alb < 39.75 g/L, NLR ≥ 2.39

11

ALBI-PLR [105]

ALBI score + PLR score

Assign scores for ALBI (0 = <-2.60, 1 = ≥-2.6 and < -1.39, 2 =≥-1.39);  for PLR (0 = ≤ 150, 1 = > 150)

12

PNI-APRI score [38]

APRI score + PNI score

Assign score = 1 to each of the following: APRI > 0.98, PNI < 46.5

13

Baso-NLR [106]

Baso score + NLR score

Assign score = 1 to each of the following: Baso < 15 × 10⁶/L, NLR > 2.585

14

Baso-PLR [106]

Baso score + PLR score

Assign score = 1 to each of the following: Baso < 15 × 10⁶/L, PLR > 232.5

15

PI [93]

Prognostic index

CRP score + WBC score

Assign score = 1 to each of the following: CRP ≥ 10  mg/L, WBC ≥ 11 × 10⁹/L

16

LIPI [7]; LNI [12]

The lung immune prognostic index [7]; dNLR combined with LDH index [12]

dNLR score + LDH score

Assign score = 1 to each of the following: dNLR > 3, LDH > ULN [7]; or dNLR > 1.985, LDH > 244U/L [12])

17

dNLR-PNI [107]

the combination of dNLR and PNI

dNLR score + PNI score

Assign score = 1 to each of the following: dNLR > 1.7, PNI < 46

18

Eosin-NLR [106]

Eosin score + NLR score

Assign score = 1 to each of the following: Eosin < 95 × 10⁶/L, NLR > 2.585

19

Eosin-PLR [106]

Eosin score + PLR score

Assign score = 1 to each of the following: Eosin < 95 × 10⁶/L, PLR > 232.5

20

 F-NLR [108]

a combination of NLR and Fib

Fib score + NLR score

Assign score = 1 to each of the following: Fib > 3.4 g/dL, NLR > 4.1 [103]

21

COP-LMR [109, 110]

the combination of Plt and LMR

LMR score + Plt score

1) Assign score = 1 to each of the following: Plt > 221 × 10⁹ /L, LMR < 3.96) [109];

2) Assign score = 1 to each of the following: Plt > 30 × 10⁴ /µL, LMR < 3.6 [110]

22

MLR-NLR [111]

MLR score + NLR score

Assign score = 1 to each of the following: MLR > 0.36, NLR > 2.77

23

coNLR-PDW [112]

the combination of NLR and PDW

NLR score + PDW score

Assign score = 1 to each of the following: NLR > 1.59, PDW > 13.0

24

cNPS [113]; NLR-PLR score [114]

the combination of NLR and PLR

NLR score + PLR score

Assign score = 1 to each of the following: NLR > 2.461, PLR > 248.4 [114]

25

COP-NLR [115, 116]

the combination of Plt and NLR

NLR score + Plt score

1) Assign score = 1 to each of the following: Plt < 15 × 10⁴ /µL, NLR ≥ 2.0) [115]

2) Assign score = 0 for (Plt level < 300 × 10⁹ /L and NLR < 3); score = 1 for (Plt level ≥ 300 × 10⁹ /L and NLR < 3); and score = 2 for (NLR ≥ 3) [116]

26

PIV-LDH [32]

PIV score + LDH score

Assign score = 1 to each of the following: PIV > 366, LDH < 1.5×ULN

27

PLR + PNI [117]

PLR score + PNI score

Assign score = 1 to each of the following: PLR ≥ 150, PNI < 45

28

Co-PaL [118]

the combination of preAlb and Lymph

PreAlb score + Lymph score

Assign score = 1 to each of the following: preAlb < 180 mg/L, Lymph < 1.5 × 10⁹/L)