Table 7 Univariate and Multivariable analysis of factors potentially predictive of distant metastasis-free survival

Age

2765

 <  = 60

1382

Reference

 > 60

1383

1.152 (0.831–1.625)

0.273

T stage

2759

T1

573

Reference

T2&T3&T4

2186

1.974 (1.164–2.977)

0.004

1.527 (0.822–2.312)

0.313

N stage

2753

N0

1374

Reference

N1&N2&N3

1378

2.712 (1.742–3.529)

 < 0.001

1.631 (1.042–2.636)

0.034

M stage

2649

M0

1913

Reference

M1

736

7.137 (3.785–12.465)

 < 0.001

5.024 (3.607–10.143)

 < 0.001

Pathologic stage

2746

Stage I

381

Reference

Stage II&Stage III&Stage IV

2365

3.539 (1.613–5.746)

0.013

1.463 (0.607–2.594)

0.815

ER status

2731

Negative

643

Reference

Positive

2088

0.703 (0.342–1.327)

0.019

0.820 (0.492–1.393)

0.314

PR status

2716

Negative

721

Reference

Positive

1995

0.524 (0.311–0.816)

 < 0.001

0.573 (0.249–1.214)

0.073

HER2 status

1843

Negative

1449

Reference

Positive

394

1.304 (0.801–2.024)

0.526

radiation_therapy

2679

No

1163

Reference

Yes

1516

0.649 (0.434–1.407)

0.434

HSPB1

2765

Low

1382

Reference

High

1383

1.614 (1.307–1.942)

0.045