Table 6 Univariate and Multivariable analysis of factors potentially predictive of relapse-free survival

Age

4929

 <  = 60

2464

Reference

 > 60

2465

1.125 (0.832–2.056)

0.127

1.245(0.796–2.214)

0.414

T stage

4920

T1

1274

Reference

T2&T3&T4

3646

1.315 (1.007–2.731)

0.052

1.373 (0.826–3.134)

0.125

N stage

4894

N0

2143

Reference

N1&N2&N3

2751

2.215 (2.222–5.194)

 < 0.001

2.853 (1.321–5.317)

0.013

M stage

4801

M0

4637

Reference

M1

164

6.153 (3.064–12.612)

 < 0.001

5.132 (3.428–13.241)

 < 0.001

Pathologic stage

4887

Stage I

1035

Reference

Stage II&Stage III&Stage IV

3852

3.491 (1.613–7.423)

0.007

1.307 (0.403–3.459)

0.749

ER status

4872

Negative

938

Reference

Positive

3934

0.459 (0.313–0.725)

0.003

0.413 (0.213–0.728)

0.045

PR status

4860

Negative

1104

Reference

Positive

3756

0.617 (0.414–0.876)

0.017

0.834 (0.414–1.625)

0.407

HER2 status

4507

Negative

3754

Reference

Positive

753

1.603 (0.629–2.714)

0.315

radiation_therapy

4736

No

1975

Reference

Yes

2761

0.691 (0.315–1.176)

0.453

HSPB1

4929

Low

2464

Reference

High

2465

1.479 (1.124–1.893)

0.038