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Table 1 General information on previous studies about RNSM

From: Mastectomy with Reconstruction Including Robotic Endoscopic Surgery (MARRES): a prospective cohort study of the Korea Robot-Endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG) and Korean Breast Cancer Study Group (KBCSG)

Study

Year

Study interval

Aim

Design

No. of patients (procedures)

Indication (n, %)

Ryu et al. [19]

2020

Nov 2016–Jan 2020

To report the early experience of RNSM with IBR in the KoREa-BSG

Retrospective case series, multicenter

73 (82)

Therapeutic (75, 91.5%)Risk-reducing (7, 8.5%)

Lee et al. [41]

2021

Nov 2016–Jan 2019

To directly compare surgical outcomes between CNSM and RNSM

Retrospective case–control comparison study, single center

CNSM 270

RNSM 41

Therapeutic (34, 83%)

Risk-reducing (7, 17.1%)

Toesca et al. [42]

2019

June 2014–Jan 2019

To present and discuss perioperative surgical outcomes and early oncologic follow-up data on consecutive patients undergoing RNSM

Prospective case series, single center

73 (94)

Invasive breast cancer (39, 41.5%)

DCIS (21, 223%)

Risk-reducing (34, 36.2%)

Sanson et al. [43]

2018

Nov 2015–Jan 2020

To report the feasibility of RNSM with a large series of 138 procedures

Prospective, single center

79 (138)

Prophylactic (75%)

Therapeutic (25%)

Lai et al. [44]

2020

July 2011–Sep 2019

To critically compare RNSM vs. CNSM procedures from different aspects (clinical outcomes, patient-reported aesthetic results, and medical costs) in the management of patients with breast cancer

Retrospective case–control comparison study, single center

CNSM 62

RNSM 54

Therapeutic

Houvenaeghel et al. [45]

2021

Nov 2016–Mar 2020

To compare RNSM and CNSM in terms of the breast complication rate (main objective) and hospital stay, duration of surgery, cost evaluation, and patient satisfaction (secondary objectives)

Prospective case–control comparison study, single center

CNSM 142

RNSM 87

Primary (70, 80.5%)

Local recurrence (10, 11.5%)

Prophylactic (7, 8.0%)

Loh et al. [46]

2020

April 2018–Jan 2020

To report the use of RNSM in patients with breast cancer and analyze the learning curve of one surgeon in a single medical center

Retrospective single center

78 (85)

Therapeutic

Kuo et al. [47]

2019

N/A

To report the combination of robotic mastectomy and immediate microsurgical free-flap reconstruction and exploit its oncologic and aesthetic advantages

Case series, single center

3

Therapeutic

  1. CNSM conventional nipple-sparing mastectomy, IBR immediate breast reconstruction, KoREa-BSG Korea Robot-Endoscopy Minimal Access Breast Surgery Study Group, RNSM robotic nipple-sparing mastectomy