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Fig. 7 | BMC Cancer

Fig. 7

From: Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing

Fig. 7

Integration recovers matching cell states from different dissociation methods for OS. A UMAP embeddings after integration (bottom row) showed alignment of matching PDX specimens. B After integration (bottom row), clusters on the UMAP were no longer affected by the identified biases. Darker blue indicates higher expression. C Dot plot of conserved markers shows unique gene expression for each PDX. The top marker is in red. D After integration (right column), top conserved markers are correctly aligned with the associated PDX cluster

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BMC Cancer

ISSN: 1471-2407

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