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Fig. 5 | BMC Cancer

Fig. 5

From: Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing

Fig. 5

Biases associated with protocol on Sarcoma-specific signatures. Boxplots display the data distributions (centerline: median, box limits: first and third quartiles, and the whiskers are the highest and lowest values that are no greater and smaller than 1.5 × the interquartile range) of the sarcoma-specific signatures. A post hoc one-sided test with Bonferroni correction and defined contrasts for each sarcoma subtype vs. the rest for each signature was performed. We report a significant difference (p < 2e-16) where the sarcoma subtype was greater than the rest by outlining the graph with a red border. EWS-FLI1 ES signature is derived from a gene set of EWS-FLI1 target genes. EWS-WT1 DSRCT signature is derived from a gene set of EWS-WT1 target genes. Both osteoblastic and chondroblastic signatures are gene sets derived from reference databases

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BMC Cancer

ISSN: 1471-2407

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