Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1

BMC Cancer

Table 2 MM incidence and organoid lines derived from p53^+/- and wild-type C57BL6 mouse

Mouse genotype	Material	Total number	Mesothelioma incidence		Established organoids
Mouse genotype	Material	Total number	Number	%	Number	%
P53 +/-	Crocidolite	14	6	42.9	5	83.3
	NT50	10(3)	3	42.9	1	33.3
	NT	8	0	0.0	0	ND
P53 + / +	Crocidolite	10(1)	1	11.1	1	100.0
	NT50	4(2)	1	50.0	0	0
	NT	7	0	0.0	0	ND

The total number includes mice died from ileus resulting from peritonitis in parentheses. Mesothelioma incidence: mesothelioma/[total number-ileus] (%). Established organoid: the number of established organoids/number or mesothelioma incidence (%). NT Carbon nanotube, NT No treatment, ND Not determined. Refer to text for details

ISSN: 1471-2407