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Fig. 2 | BMC Cancer

Fig. 2

From: Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1

Fig. 2

MM organoids require epidermal growth factor through EGFR. a The images of MM organoids at 7 days (scale bar = 1 mm). MM-organoids were incubated with or without growth factors. Organoid growth factors: EGF (E), NOGGIN (N or NOG), R-Spondin1 (R or R-spo), Fibroblast Growth Factor (FGF), Hydrocortisone (HC). b The sizes of individual MM-organoids after co-incubation with EGF, NOGGIN, R-spondin1, Wnt3A, Fibroblast Growth Factor (FGF) and/or Hydrocortisone (HC). Gray, no growth factor; light green, all essential growth factor (ENR; EGF, NOGGIN and R-spondin1); green, ENR minus single essential growth factor; dark green; ENR plus other growth factor. c Immunoblot analysis of receptor tyrosine kinase in the 2D normal mesothelial and MM cell lines. d Immunoblot analysis of tumor suppressor proteins in the 2D normal mesothelial and MM cell-lines

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BMC Cancer

ISSN: 1471-2407

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