Table 1 Selected upstream regulator pathways. The pathways predicted to be activated are listed on the left side of the z-score column, while those predicted to be inhibited listed on the right side. A z-score ≥ 2 predicts an activation state, while a z-score ≤ -2 predicts an inhibitory state of the pathway. For targeted molecule information, refer to S1-S3 Tables
RNA-Seq | Category | Upstream Regulator | Activation z-score | p-value of overlap |
|---|---|---|---|---|
D2 vs. SCC | Cell Cycle | TP53 | 2.056 | 0.00019 |
Cytokine | TNF | 3.663 | 1.77E-11 | |
IL1b | 2.837 | 0.00018 | ||
IFNg | 2.811 | 0.0312 | ||
OSM | 2.211 | 0.0156 | ||
IL1a | 2.007 | 0.00542 | ||
Growth factor | VEGFa | 2.771 | 0.00084 | |
EGF | 2.585 | 0.0374 | ||
D3 vs. SCC | Cell Cycle | CDKN1A | 2.532 | 2.2E-05 |
TP53 | 2.928 | 1.34E-12 | ||
CDKN2A | 2.07 | 0.00735 | ||
Cytokine | TNF | 2.018 | 1.85E-11 | |
Growth factor | VEGFa | 2.244 | 0.00153 | |
FGF7 | -2.169 | 0.00779 | ||
AREG | -3.352 | 9.53E-06 | ||
D2 vs. D3 | Cell Cycle | CDKN1A | -2.266 | 5.7E-07 |
TP53 | -3.37 | 8.49E-14 | ||
CCNK | 2.366 | 0.00246 | ||
Cytokine | IL6 | 2.021 | 0.0126 | |
Growth factor | AREG | 2.917 | 8.30E-10 | |
FGF7 | 2.028 | 0.0114 |