Table 4 Univariate and multivariate analysis for recurrence-free survival (RFS) predictors in 38 patients with BCBM that were removed by gross total resection
Characteristics | No. | Mean (months) | P-value (univariate) | P-value (multivariate) | Hazard ratio | 95% CI | |
|---|---|---|---|---|---|---|---|
Age (year) | < 60 | 25 | 48.5 | 0.780 | 0.275 | 1 | 0.571–7.164 |
≥ 60 | 13 | 31.8 | 2.023 | ||||
Sex | Female | 37 | --- | --- | --- | ||
Male | 1 | --- | |||||
Molecular type | Non-TN | 26 | 52.5 | 0.063 | 0.029 | 1 | 1.158–15.256 |
TN | 12 | 13.5 | 4.202 | ||||
CAF pattern | Type B | 15 | 43.2 | 0.424 | 0.254 | 1 | 0.112–1.782 |
Others | 23 | 41.8 | 0.447 | ||||
PDGFR-β | Low | 21 | 31.2 | 0.011 | 0.030 | 1 | 0.060–0.868 |
High | 17 | 50.1 | 0.228 | ||||
α-SMA | Low | 20 | 28.3 | 0.080 | --- | ||
High | 18 | 56.4 | |||||
Tumor location | Supratentorial | 29 | 45.3 | 0.968 | --- | ||
Infratentorial | 9 | 25.6 | |||||
Extracranial Mets | Absent | 10 | 28.0 | 0.074 | 0.072 | 1 | 0.106–1.099 |
Present | 28 | 44.0 | 0.341 | ||||
BM symptom | Mild to moderate | 24 | 48.3 | 0.500 | --- | ||
Severe | 14 | 33.4 | |||||
KPS | ≥ 80 | 25 | 44.1 | 0.806 | --- | ||
< 80 | 13 | 38.5 | |||||
BM multiplicity | Single | 20 | 32.9 | 0.066 | --- | ||
Multiple | 18 | 48.1 | |||||
BM development | Metachronous | 37 | --- | --- | --- | ||
Synchronous | 1 | --- | |||||
BM size | < 4 cm | 19 | 39.0 | 0.428 | --- | ||
≥ 4 cm | 19 | 41.3 | |||||
Peritumoral edema | Mild to moderate | 16 | 38.9 | 0.676 | --- | ||
Severe | 22 | 43.7 | |||||
Tumor nature | Solid | 23 | 45.1 | 0.919 | --- | ||
Cystic or mixed | 15 | 38.6 | |||||
Postoperative RT/GKS | Absent | 9 | 22.8 | 0.249 | --- | ||
Present | 29 | 42.2 | |||||