Skip to main content

Table 3 Aggregated costs (in 2022€) for diagnostic, preventive, and therapeutic procedures. All Women receive intensified surveillance for breast cancer as standard care. Prophylactic surgeries, initial treatment and palliative care are assumed to occur only once at a one-time cost. Follow-up costs are annual costs over 5 and 10 years after cancer diagnosis for ovarian and breast cancer, respectively. All costs are based on the published literature [21]

From: Decision-analytic evaluation of the comparative effectiveness and cost-effectiveness of strategies to prevent breast and ovarian cancer in German women with BRCA-1/2 mutations

Procedure

Costs (in 2022€)

Standard care and prophylactic surgeries

 

Standard care (intensified surveillance for breast cancer) *

608

PBM §

9,032

PBSO §

3,099

PBM + PBSO§

12,131

Initial cancer treatment (surgery, drugs, radiotherapy etc.) §

 

Breast cancer (pT1-pT3) (incl. standard care)

20,092

 After PBM

14,333

 After PBSO

20,092

 After PBM + PBSO

14,333

Breast cancer (metastatic) (incl. standard care)

30,623

 After PBM

24,865

 After PBSO

30,623

 After PBM + PBSO

24,865

Ovarian cancer (non-advanced FIGO I-II) (incl. standard care)

13,666

 After PBM

13,666

 After PBSO

11,280

 After PBM and PBSO

11,280

Ovarian cancer (advanced FIGO III-IV) (incl. standard care)

35,052

 After PBM

35,052

 After PBSO

32,666

 After PBM and PBSO

32,666

Palliative care costs §

 

 Metastatic/end stage breast cancer

12,103

 Metastatic/end stage ovarian cancer

12,103

Annual follow-up costs

 

Breast cancer (incl. Standard care); 10 years of follow up*

 

 pT1

595

 pT2

652

 pT3

589

 pT4

686

 pT1 after PBM

443

 pT2 after PBM

500

 pT3 after PBM

437

 pT4 after PBM

534

 pT1 after PBSO

595

 pT2 after PBSO

652

 pT3 after PBSO

589

 pT4 after PBSO

686

 pT1 after PBM and PBSO

443

 pT2 after PBM and PBSO

500

 pT3 after PBM and PBSO

437

 pT4 after PBM and PBSO

534

Ovarian cancer (incl. Standard care); 5 years of follow up*

 

 Non-advanced (FIGO I + II)

1,356

 Advanced (FIGO III + IV)

2,389

 Non-advanced (FIGO I + II) after PBM

1,052

 Advanced (FIGO III + IV) after PBM

2,085

 Non-advanced (FIGO I + II) after PBSO

1,214

 Advanced (FIGO III + IV) after PBSO

2,246

 Non-advanced (FIGO I + II) after PBM and PBSO

910

 Advanced (FIGO III + IV) after PBM and PBSO

1,942

  1. FIGO I-IV: ovarian cancer stage FIGO grade 1–4; incl.: including; PBM: Prophylactic bilateral mastectomy; PBSO: Prophylactic bilateral salpingo-oophorectomy; pT1-4: breast cancer stage grade pT1-pT4
  2. *annual costs
  3. § one-time costs