Skip to main content

Table 2 Utilities used for different health states in the model.

From: Decision-analytic evaluation of the comparative effectiveness and cost-effectiveness of strategies to prevent breast and ovarian cancer in German women with BRCA-1/2 mutations

Health status

Utility (SD)

Reference

Well at age 30 with BRCA-1/2 mutation

0.92 (0.15)

Grann et al. 2010 [42]*

Breast cancer

 

pT1

0.68 (0.06)

Schleinitz et al., 2006 [43] §

pT2

0.61 (0.06)

Schleinitz et al., 2006 [43] §

pT3

0.56 (0.06)

Schleinitz et al., 2006 [43] §

pT4/ metastatic

0.42 (0.06)

Schleinitz et al., 2006 [43] §

Clinical remission (breast cancer survivors)

0.83 (0.24)

Havrilesky et al., 2009 [44]

Ovarian cancer

 

FIGO I

0.81

Havrilesky et al., 2009; Kearns et al., 2016 [44, 45]*

FIGO II

0.72

Havrilesky et al., 2009; Kearns et al., 2016 [44, 45] *

FIGO III

0.63

Havrilesky et al., 2009; Kearns et al., 2016 [44, 45] *

FIGO IV/metastatic

0.55

Havrilesky et al., 2009; Kearns et al., 2016 [44, 45] *

Clinical remission (ovarian cancer survivors)

0.83 (0.25)

Havrilesky et al., 2009 [44]

Prophylactic surgeries

PBM

0.88 (0.24)

Grann et al., 2011 [33]*

PBSO

0.95 (0.24)

Grann et al., 2011 [33]*

PBM + PBSO

0.84 (0.25)

Grann et al., 2011 [33]*

  1. FIGO I-IV: ovarian cancer stage FIGO 1–4; MRI: Magnetic resonance imaging; PBM: Prophylactic bilateral mastectomy; PBSO: Prophylactic bilateral salpingo-oophorectomy; pT1-4: breast cancer stage pT1-pT4
  2. Utility values for undetected cancer were approximated using utility values for patients without depression or depression-like symptoms. For details see Additional file 2
  3. * Time trade-off (TTO) method to estimate utility
  4. § Standard Gamble (SG) approach to estimate utility
  5. † Utility for Breast cancer clinical remission is assumed to be the same as for ovarian cancer clinical remission