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Table 3 Top five regimens and their time to discontinuation

From: Survival differences between patients with de novo and relapsed/progressed advanced non-small cell lung cancer without epidermal growth factor receptor mutations or anaplastic lymphoma kinase rearrangements

 

Number of patients (%)

Time to treatment discontinuation (months), mean (SD)

Total

De novo patients

Relapsed/progressed patients

Total

De novo patients

Relapsed/progressed patients

First-line regimen

14,505 (100.0)

12,811 (100.0)

1,694 (100.0)

2.9 (2.7)

2.8 (2.5)

3.0 (4.0)

 Paclitaxel + platinum

4,758 (32.8)

4,387 (34.2)

371 (21.9)

2.8 (2.9)

2.8 (2.9)

2.5 (2.8)

 Pemetrexed + platinum

4,063 (28.0)

3,763 (29.4)

300 (17.7)

2.7 (1.3)

2.7 (1.3)

2.6 (1.1)

 Gemcitabine + platinum

4,042 (27.9)

3,631 (28.3)

411 (24.3)

2.9 (2.7)

2.9 (2.4)

3.1 (4.3)

 Gemcitabine

430 (3.0)

337 (2.6)

93 (5.5)

2.8 (4.8)

2.8 (5.2)

2.6 (3.0)

 Docetaxel + platinum

329 (2.3)

295 (2.3)

34 (2.0)

3.1 (2.1)

3.2 (2.1)

2.2 (1.7)

 Others

883 (6.1)

398 (3.1)

485 (28.6)

3.6 (4.9)

3.4 (4.1)

3.7 (5.4)

Second-line regimen

5.973 (100.0)

5,314 (100.0)

659 (100.0)

3.8 (4.9)

3.7 (4.9)

3.8 (5.1)

 Docetaxel

1,127 (18.9)

996 (18.7)

131 (19.9)

2.4 (2.3)

2.4 (2.3)

2.3 (1.9)

 Gemcitabine + platinum

946 (15.8)

860 (16.2)

86 (13.1)

2.6 (2.3)

2.6 (2.4)

2.5 (1.9)

 Pembrolizumab

822 (13.8)

765 (14.4)

57 (8.7)

7.0 (7.6)

6.9 (7.5)

8.7 (8.6)

 Nivolumab

688 (11.5)

617 (11.6)

71 (10.8)

6.0 (7.0)

5.9 (6.9)

6.6 (8.1)

 Paclitaxel + platinum

404 (6.8)

373 (7.0)

31 (4.7)

2.7 (3.9)

2.7 (3.8)

3.3 (5.3)

 Others

1,986 (33.3)

1,703 (32.1)

283 (42.9)

3.2 (3.9)

3.1 (3.8)

3.3 (3.9)

  1. SD, standard deviation
  2. All percentages may not add to a total of 100% because of rounding.