Table 3 Combined effect of smoking, alcohol consumption, and HPV16 serology on risk of OSCC, stratified by tumor sites
Risk factors | HPV16 status | Controls (n = 433) | Cases (n = 377) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | % | OSCC (All cases) | SCCOP | SCCOC | ||||||||
n | % | aORa (95% CI) | n | % | aORa (95% CI) | n | % | aORa (95% CI) | ||||
211 | 56.0 | 166 | 44.0 | |||||||||
Smoking | ||||||||||||
Never | − | 106 | 24.5 | 65 | 17.2 | 1.0 | 27 | 12.8 | 1.0 | 38 | 22.9 | 1.0 |
+ | 40 | 9.2 | 50 | 13.3 | 2.1 (1.2–3.6) | 45 | 21.3 | 4.9 (2.6–9.2) | 5 | 3.0 | 0.3 (0.1–0.9) | |
Ever | − | 273 | 63.1 | 203 | 53.9 | 1.2 (0.8–1.7) | 94 | 44.6 | 1.4 (0.8–2.4) | 109 | 65.7 | 1.2 (0.7–1.9) |
+ | 14 | 3.2 | 59 | 15.6 | 6.8 (3.4–13.4) | 45 | 21.3 | 13.0 (6.0–27.7) | 14 | 8.4 | 2.5 (1.0–6.1) | |
Alcohol consumption | ||||||||||||
Never | − | 137 | 31.6 | 60 | 15.9 | 1.00 | 22 | 10.4 | 1.0 | 38 | 22.9 | 1.0 |
+ | 15 | 3.5 | 28 | 7.4 | 2.3 (1.7–8.8) | 20 | 9.5 | 5.1 (3.0–20.7) | 8 | 4.8 | 1.5 (0.6–4.0) | |
Ever | − | 242 | 55.9 | 208 | 55.2 | 1.8 (1.2–2.7) | 99 | 46.9 | 1.8 (1.2–4.1) | 109 | 65.7 | 1.4 (0.8–2.2) |
+ | 39 | 9.0 | 81 | 21.5 | 4.8 (2.9–8.0) | 70 | 33.3 | 10.8 (5.8–20.1) | 11 | 6.6 | 0.8 (0.3–1.8) | |