Table 2 Effect of smoking, alcohol consumption, and HPV16 serology on risk of OSCC, stratified by tumor sites
Risk factors | Controls (n = 433) | Cases (n = 377) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
n | % | OSCC (All cases) | SCCOP | SCCOC | |||||||
n | % | aORa (95% CI) | n | % | aORa (95% CI) | n | % | aORa (95% CI) | |||
433 | 100 | 377 | 100 | 211 | 56.0 | 166 | 44.0 | ||||
Smoking | |||||||||||
Never | 146 | 33.7 | 115 | 30.5 | 1.0 | 72 | 34.1 | 1.0 | 43 | 25.9 | 1.0 |
Ever | 287 | 66.3 | 262 | 69.5 | 1.4 (1.0–2.0) | 139 | 65.9 | 1.6 (1.1–2.6) | 123 | 74.1 | 1.4 (1.1–2.2) |
Alcohol consumption | |||||||||||
Never | 152 | 35.1 | 88 | 23.3 | 1.0 | 42 | 19.9 | 1.0 | 46 | 27.7 | 1.0 |
Ever | 281 | 64.9 | 289 | 76.7 | 1.6 (1.1–2.2) | 169 | 80.1 | 1.7 (1.1–2.7) | 120 | 72.3 | 1.4 (1.1–2.3) |
HPV16 status | |||||||||||
Seronegative | 379 | 87.5 | 268 | 71.1 | 1.0 | 121 | 57.4 | 1.0 | 147 | 88.5 | 1.0 |
Seropositive | 54 | 12.5 | 109 | 28.9 | 3.3 (2.2–4.9) | 90 | 42.6 | 6.6 (4.2–10.3) | 19 | 11.5 | 1.0 (0.5–1.6) |