Fig. 3
From: Prognostic value of tumor necrosis based on the evaluation of frequency in invasive breast cancer
Subclassification of TN in IBC. A TN1, a kind of TN pattern surrounded by tumor cells and SHG images showed that tumor cells separated collagen fibers from necrotic lesions. B TN2, a kind of TN pattern surrounded by collagen fibers, and no tumor cells were observed between the necrotic lesions and collagen fibers. C TN3, a kind of TN pattern surrounded by myoepithelium, and no tumor cells were observed between necrotic lesions and myoepithelium, and SHG images showed that myoepithelium separated collagen fibers from necrotic lesions. D TN4, a kind of TN pattern with multiple components surrounding the necrotic lesions. M: myoepithelium. Scale bar: 100 μm