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Fig. 3 | BMC Cancer

Fig. 3

From: ATF2 loss promotes 5-FU resistance in colon cancer cells via activation of the ATR-Chk1 damage response pathway

Fig. 3

ATF2 loss induces a resistant pattern in CAM xenografts. The immunohistochemistry panel shows (a) ATF2 and (b) Ki67, γ-H2AX, and p-Chk1Ser317 staining of formalin-fixed paraffin-embedded (FFPE) tumor tissues harvested from the CAM. The tumors formed by 120 h inoculation with 5-FU or normal medium (ctrl) as a control in HCT116, E5, and F9 cells. The scanned images of CAM sections were taken at 10X magnification (overview sections, scale bar: 200 μm) and 50X magnification (black box circled the detailed area; scale bar: 40 μm)

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BMC Cancer

ISSN: 1471-2407

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