Table 3 Multivariate Cox regression analysis of RFS for patients with stage II CRC in the two cohorts
From: Size and number of lymph nodes were risk factors of recurrence in stage II colorectal cancer
Variables | Training cohort(n = 176) | Validation cohort(n = 175) | ||||
|---|---|---|---|---|---|---|
Hazard ratio | 95%CI | P | Hazard ratio | 95%CI | P | |
Age | 0.747 | 0.339 | ||||
< 60 | 1.00 | 1.00 | ||||
≥60 | 0.886 | 0.425–1.846 | 1.396 | 0.705–2.765 | ||
Sex | 0.958 | 0.914 | ||||
Male | 1.00 | 1.00 | ||||
Female | 0.980 | 0.466–2.060 | 0.965 | 0.505–1.843 | ||
Histology | 0.570 | 0.733 | ||||
Adenocarcinoma | 1.00 | 1.00 | ||||
Mucinous tumors | 0.724 | 0.238–2.204 | 1.177 | 0.462–2.996 | ||
T stage | 0.499 | 0.717 | ||||
T3 | 1.00 | 1.00 | ||||
T4 | 1.292 | 0.615–2.714 | 0.879 | 0.438–1.764 | ||
Pathological grading | 0.905 | 0.448 | ||||
Well and moderate | 1.00 | 1.00 | ||||
Poor and anaplastic | 1.060 | 0.410–2.741 | 1,397 | 0.589–3.313 | ||
SLNs | 0.039 | 0.003 | ||||
D ≤ 5.8 | 1.00 | 1.00 | ||||
D > 5.8 | 2.361 | 1.044–5.338 | 2.979 | 1.435–5.184 | ||
NLNs | 0.049 | 0.021 | ||||
N ≤ 22 | 1.00 | 1.00 | ||||
N > 22 | 0.335 | 0.113–0.994 | 0.375 | 0.156-0.900 | ||