Table 2 Univariate Cox regression analysis of RFS for patients with stage II CRC in the two cohorts
From: Size and number of lymph nodes were risk factors of recurrence in stage II colorectal cancer
Variables | Training cohort(n = 176) | Validation cohort(n = 175) | ||||
|---|---|---|---|---|---|---|
Hazard ratio | 95%CI | P | Hazard ratio | 95%CI | P | |
Age | 0.902 | 0.304 | ||||
< 60 | 1.00 | 1.00 | ||||
≥60 | 0.957 | 0.479–1.915 | 1.388 | 0.743–2.591 | ||
Sex | 0.905 | 0.874 | ||||
Male | 1.00 | 1.00 | ||||
Female | 0.958 | 0.473–1.940 | 1.051 | 0.567–1.948 | ||
Histology | 0.616 | 0.230 | ||||
Adenocarcinoma | 1.00 | 1.00 | ||||
Mucinous tumors | 0.765 | 0.268–2.182 | 1.524 | 0.766–3.032 | ||
Tumor location | 0.596 | 0.976 | ||||
Left-sided | 1.00 | 1.00 | ||||
Right-sided | 0.829 | 0.415–1.658 | 0.991 | 0.541–1.816 | ||
T stage | 0.572 | 0.387 | ||||
T3 | 1.00 | 1.00 | ||||
T4 | 1.228 | 0.603–2.502 | 0.742 | 0.377–1.459 | ||
Adjuvant chemotherapy | 0.405 | 0.245 | ||||
No | 1.00 | 1.00 | ||||
Yes | 1.464 | 0.597–3.586 | 1.554 | 0.739–3.268 | ||
Pathological grading | 0.735 | 0.145 | ||||
Well and moderate | 1.00 | 1.00 | ||||
Poor and anaplastic | 1.167 | 0.477–2.856 | 1.654 | 0.841–3.255 | ||
Venous invasion | 0.551 | 0.123 | ||||
Negative | 1.00 | 1.00 | ||||
Positive | 0.546 | 0.074–3.999 | 1.978 | 0.832–4.706 | ||
Perineural invasion | 0.848 | 0.538 | ||||
Negative | 1.00 | 1.00 | ||||
Positive | 0.903 | 0.317–2.575 | 0.723 | 0.258–2.027 | ||
CEA (ng/ml) | 0.606 | 0.412 | ||||
≤5 | 1.00 | 1.00 | ||||
>5 | 0.826 | 0.401–1.702 | 0.738 | 0.357–1.525 | ||
MMR status | 0.598 | 0.380 | ||||
pMMR | 1.00 | 1.00 | ||||
dMMR | 0.823 | 0.399–1.697 | 1.375 | 0.676–2.797 | ||
SLNs | 0.048 | 0.005 | ||||
D ≤ 5.8 | 1.00 | 1.00 | ||||
D > 5.8 | 2.179 | 1.008–4.711 | 2.768 | 1.361–5.632 | ||
NLNs | 0.043 | 0.049 | ||||
N ≤ 22 | 1.00 | 1.00 | ||||
N > 22 | 0.339 | 0.119–0.966 | 0.446 | 0.198–1.004 | ||