Table 1 Baseline demographic and clinicopathological characteristics of stage II CRC patients by SLNs and NLNs
From: Size and number of lymph nodes were risk factors of recurrence in stage II colorectal cancer
Characteristic | Training cohort | Validation cohort | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases | D | P | N | P | Cases | D | P | N | P | |||||
N(%) | ≤ 5.8 | > 5.8 | ≤ 22 | > 22 | N(%) | ≤ 5.8 | > 5.8 | ≤ 22 | > 22 | |||||
No. of patients | 176(100.0) | 79(44.9) | 97(55.1) | 127(72.2) | 49(27.8) | 175(100.0) | 78(44.6) | 97(55.4) | 125(71.4) | 50(28.6) | ||||
Age | 0.672 | 0.002 | 0.455 | 0.060 | ||||||||||
<60 | 86(48.9) | 40(46.5) | 46(53.5) | 53(61.6) | 33(38.4) | 75(42.9) | 31(41.3) | 44(58.7) | 48(64.0) | 27(36.0) | ||||
≥60 | 90(51.1) | 39(43.3) | 51(56.7) | 74(82.2) | 16(9.1) | 100(57.1) | 47(47.0) | 53(53.0) | 77(77.0) | 23(23.0) | ||||
Sex | 0.587 | 0.023 | 0.841 | 0.559 | ||||||||||
Male | 103(58.5) | 48(46.6) | 55(53.4) | 81(78.6) | 22(21.4) | 104(59.4) | 47(45.2) | 57(54.8) | 76(73.1) | 28(26.9) | ||||
Female | 73(41.5) | 31(42.5) | 42(57.5) | 46(63.0) | 27(37.0) | 71(40.6) | 31(43.7) | 40(56.3) | 49(69.0) | 22(31.0) | ||||
Histology | 0.373 | 0.809 | 0.225 | 0.904 | ||||||||||
Adenocarcinoma | 149(84.7) | 69(46.3) | 80(53.7) | 107(71.8) | 20(28.2) | 141(80.6) | 66(46.8) | 75(53.2) | 101(71.6) | 40(28.4) | ||||
Mucinous tumors | 27(15.3) | 10(37.0) | 17(63.0) | 42(74.1) | 7(25.9) | 34(19.4) | 12(35.3) | 22(64.7) | 24(70.6) | 10(29.4) | ||||
Tumor location | 0.128 | 0.023 | 0.091 | 0.094 | ||||||||||
Left-sided | 78(44.3) | 40(51.3) | 38(48.7) | 63(80.8) | 15(19.2) | 84(48.0) | 43(51.2) | 41(48.8) | 65(77.4) | 19(22.6) | ||||
Right-sided | 98(55.7) | 39(39.8) | 59(60.2) | 64(65.3) | 34(34.7) | 91(52.0) | 35(38.5) | 56(61.5) | 60(65.9) | 31(34.1) | ||||
T stage | 0.512 | 0.168 | 0.415 | 0.918 | ||||||||||
T3 | 118(67.0) | 55(46.6) | 63(53.4) | 89(75.4) | 29(24.6) | 120(68.6) | 51(42.5) | 69(57.5) | 86(71.7) | 34(28.3) | ||||
T4 | 58(33.0) | 24(41.4) | 34(58.6) | 38(65.5) | 20(34.5) | 55(31.4) | 27(49.1) | 28(50.9) | 39(70.9) | 16(29.1) | ||||
Adjuvant chemotherapy | 0.507 | 0.135 | 0.695 | 0.082 | ||||||||||
No | 48(27.3) | 20(41.7) | 28(58.3) | 34(70.8) | 14(29.2) | 53(30.3) | 26(49.1) | 27(50.9) | 44(83.0) | 9(17.0) | ||||
Yes | 122(69.3) | 55(45.1) | 67(54.9) | 87(71.3) | 35(28.7) | 119(68.0) | 51(42.9) | 68(57.1) | 79(66.4) | 40(33.6) | ||||
Unknown | 6(3.4) | 4(66.7) | 2(33.3) | 6(100.0) | 0(0) | 3(1.7) | 1(33.3) | 2(66.7) | 2(66.7) | 1(33.3) | ||||
Pathological grading | 0.575 | 0.168 | 0.017 | 0.964 | ||||||||||
Well & moderate | 142(80.7) | 65(45.8) | 77(54.2) | 99(69.7) | 43(30.3) | 131(74.9) | 63(48.1) | 68(51.9) | 94(71.8) | 37(28.2) | ||||
Poor & anaplastic | 31(17.6) | 12(38.7) | 19(61.3) | 25(80.6) | 6(19.4) | 38(21.7) | 15(39.5) | 23(60.5) | 27(71.1) | 11(28.9) | ||||
Unknown | 3(1.7) | 2(66.7) | 1(33.3) | 3(100.0) | 0(0) | 6(3.4) | 0(0) | 6(100.0) | 4(66.7) | 2(33.3) | ||||
Venous invasion | 1.00 | 0.448 | 0.709 | 0.898 | ||||||||||
Negative | 167(94.9) | 75(44.9) | 92(55.1) | 122(73.1) | 45(26.9) | 160(91.4) | 72(45.0) | 88(55.0) | 115(71.9) | 45(28.1) | ||||
Positive | 9(5.1) | 4(44.4) | 5(55.6) | 5(55.6) | 4(44.4) | 15(8.6) | 6(40.0) | 9(60.0) | 10(66.7) | 5(33.3) | ||||
Perineural invasion | 0.162 | 0.644 | 0.088 | 1.000 | ||||||||||
Negative | 151(85.8) | 71(47.0) | 80(53.0) | 108(71.5) | 43(28.5) | 154(88.0) | 65(42.2) | 89(57.8) | 110(71.4) | 44(28.6) | ||||
Positive | 25(14.2) | 8(32.0) | 17(68.0) | 19(76.0) | 6(24.0) | 21(12.0) | 13(61.9) | 8(38.1) | 15(71.4) | 6(28.6) | ||||
CEA (ng/ml) | 0.217 | 0.576 | 0.571 | 0.608 | ||||||||||
≤5 | 93(52.8) | 36(38.7) | 57(61.3) | 64(68.8) | 29(31.2) | 108(61.7) | 48(44.4) | 60(55.6) | 75(69.4) | 33(30.6) | ||||
>5 | 71(40.3) | 37(52.1) | 34(47.9) | 54(76.1) | 17(23.9) | 51(29.1) | 21(41.2) | 30(58.8) | 37(72.5) | 14(27.5) | ||||
Unkown | 12(6.8) | 6(50.0) | 6(50.0) | 9(75.0) | 3(25.0) | 16(9.1) | 9(56.2) | 7(43.8 | 13(81.3) | 3(18.8) | ||||
MMR status | 0.037 | 0.089 | 0.009 | 0.501 | ||||||||||
pMMR | 134(76.1) | 66(49.3) | 68(50.7) | 101(75.4) | 33(24.6) | 142(81.1) | 70(49.3) | 72(50.7) | 103(72.5) | 39(27.5) | ||||
dMMR | 42(23.9) | 13(31.0) | 29(69.0) | 26(61.9) | 16(38.1) | 33(18.9) | 8(24.2) | 25(75.8) | 22(66.7) | 11(33.3) | ||||