Table 8 Differential receptor expression in PDX mice bearing Black and White pancreatic cancer tumors after treatment with GemHCl and 4NSG-SLN with their respective staining scores analysis

EGFR

 % Positive

25 ± 2.3

26.3 ± 4.4

25 ± 4.5

14.2 ± 5.5

0.043

20 ± 10

5 ± 2.2

0.562

 % Weak Positive Cells

1.3 ± 0.1

1.9 ± 1.3

1.4 ± 0.1

7.3 ± 2.9

2.7 ± 0.7

2.7 ± 1 ± .4

 % Moderate Positive Cells

0.3 ± 0.1

0.5 ± 0.4

0.6 ± 0.2

3.1 ± 2.1

3.1 ± 2.1

0.9 ± 0.7

 % Strong Positive Cells

0.4 ± 0.1

0.4 ± 0.1

0.5 ± 0.1

3.8 ± 0.5

2.3 ± 1.5

0.8 ± 0.1

 %Negative Cells

73 ± 3.1

70.9 ± 0.2

72.5 ± 1.5

71.6 ± 2.4

71.9 ± 1.6

90.6 ± 0.9

 H Score

10.4

6.2

3.0

31.0

22.1

9.4

HER2

 % Positive

18.4 ± 0.6

27.3 ± 2.3

17.2 ± 1.0

2.3 ± 1.2

0.020

19.9 ± 1.5

3.6 ± 1.9

0.008

 % Weak Positive Cells

26.8 ± 0.8

11.2 ± 1.3

9.3 ± 1.4

11.8 ± 0.9

8.9 ± 0.8

2.7 ± 1.4

 % Moderate Positive Cells

12 ± 1.0

4.1 ± 1.2

7.2 ± 4.3

0.07 ± 0.002

10 .2 ± 1.1

0.03 ± 0.01

 % Strong Positive Cells

5.2 ± 0.6

6.3 ± 2.6

3.7 ± 0.8

1.6 ± 0.7

3.6 ± 1.2

1.5 ± 0.74

 %Negative Cells

37.6 ± 1.9

51.1 ± 0.8

62.6 ± 3.4

84.2 ± 6.1

57.4 ± 7.3

92.2 ± 6.1

 H Score

48.5

50.1

31.8

20.2

30.9

11.6

VEGF

 % Positive

33.6 ± 4.3

35.2 ± 0.1

27 ± 0.4

6.6 ± 1.8

0.010

30 ± 1.4

7.7 ± 1.4

0.006

 % Weak Positive Cells

1.8 ± 0.2

0.3 ± 0.1

1.2 ± 0.3

2.7 ± 1.4

0.7 ± 0.3

0.3 ± 0.003

 % Moderate Positive Cells

0.5 ± 0.1

0.2 ± 0.1

0.6 ± 0.2

0.4 ± 0.01

0.6 ± 0.1

0.4 ± 0.2

 % Strong Positive Cells

0.6 ± 0.2

0.4 ± 0.1

0.5 ± 0.1

0.85 ± 0.1

0.7 ± 0.3

0.5 ± 0.3

 % Strong Positive Cells

63.5 ± 1.7

63.9 ± 1.2

70.7 ± 7.8

89.5 ± 2.8

68 ± 3.8

91.1 ± 8.1

 H Score

16.1

36.6

4.7

1.4

10.0

1.8