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Table 6 Pharmacokinetic profiles after GemHCl and 4NSGSLN were administered intravenously to mice

From: Biological evaluation of novel gemcitabine analog in patient-derived xenograft models of pancreatic cancer

Parameter

Unit

Comparison

p-value

  

GemHCl

4NSG-SLN

 

k10

1/h

1.01 ± 0.03

0.36 ± 0.04

0.0001

t1/2

H

0.70 ± 0.01

1.93 ± 0.06

0.0001

Vd

mL

21.7 ± 1.9

19.3 ± 0.2

0.3619

Cl

mL/h

21.3 ± 3.2

7.1 ± 1.1

0.0001

AUC(0-t)

µg/(mL*h)

28.2 ± 4.3

86.2 ± 5.4

0.0001

  1. K10, elimination rate constant; t1/2, half-life; AUC(0-t), area under the plasma concentration–time curve; Cl Clearance, Vd Volume of distribution; (Data analyzed using t-test)
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BMC Cancer

ISSN: 1471-2407

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