Fig. 2From: SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapyA Correlation between SETD2 deleterious mutations and TMB. The difference of TMB in patients with SETD2 deleterious mutations and non-deleterious mutations across different cancer types in the GenePlus cohort. B Difference of tumor mutation burden (TMB) in patients with diverse molecular features (SETD2 deleterious mutations, BRCA1/2 deleterious mutations, MMR genes deleterious mutations, or POLE/D1 deleterious mutations) from the GenePlus cohort (Wilcoxon rank-sum test; ****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05.)Back to article page