Fig. 7

Detection of JMJD2A and cytoskeleton remodeling-related factors in CRPC docetaxel-resistant mice in in vivo experiments. A Mice PDX models of shNC and shJMJD2A groups; B Change in the tumor volume of the PDX models after treatment; C Change in the tumor weight of the PDX models after treatment; D PSA levels in mouse serum detected by ELISA; E The pathological changes in tissue samples observed by H&E staining; F miR-34a expression detected by PCR; G The levels of microtubulin α-Tubulin and β-Tubulin, F-actin in tissue samples observed by immunohistochemistry; H: JMJD2A, STMN1 and β3-Tubulin protein expression detected by western blot. ***P < 0.001, compared with the shNC group