Prediction of pathologic complete response after single-dose MR-guided partial breast irradiation in low-risk breast cancer patients: the ABLATIVE-2 trial—a study protocol

Table 2 Dose constraints for organs at risk in the ABLATIVE-2 trial

Heart	V_2.8 Gy < 10%
	V_4.7 Gy < 5%
	D_mean ≤ 1.2 Gy
	V_16Gy < 15 cc
Lungs	D_mean ≤ 2.66 Gy
Ipsilateral lung	V_6.2 Gy < 10%
Ipsilateral lung	V_12.4 Gy < 0.5 cc
Chest wall	D_20cc < 16 Gy
Chest wall	V_20Gy < 1 cc
Skin	Dose as low as possible; aim for D₀._1 cc < 12 Gy if this is not feasible aim for D₀._1 cc < 16 Gy
Optional dose constraints
Ipsilateral breast	D_mean < 5 Gy
Ipsilateral breast	PTV_CTV < 25% of total ipsilateral breast volume
Contralateral breast	No constraint, dose as low as possible

ISSN: 1471-2407