Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma

Table 4 Gene enrichment analysis based on high and low LILRB1 expression phenotype

Gene set name	NES	p.adjust	FDR
High expression
KEGG_JAK_STAT_SIGNALING_PATHWAY	2.127	0.002	0.002
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY	2.083	0.002	0.002
KEGG_CHEMOKINE_SIGNALING_PATHWAY	2.068	0.002	0.002
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	2.036	0.002	0.002
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	1.860	0.002	0.002
GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION	1.843	0.004	0.002
GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION	2.038	0.004	0.002
GO_MACROPHAGE_ACTIVATION	2.327	0.004	0.002
GO_NEUTROPHIL_CHEMOTAXIS	2.472	0.004	0.002
GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION	2.554	0.004	0.002
Low expression
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	-2.165	0.008	0.005
KEGG_CALCIUM_SIGNALING_PATHWAY	-2.128	0.006	0.004
KEGG_LONG_TERM_POTENTIATION	-2.088	0.004	0.003
KEGG_CARDIAC_MUSCLE_CONTRACTION	-2.073	0.004	0.003
GO_NEUROTRANSMITTER_TRANSPORT	-2.858	0.009	0.006
GO_SYNAPTIC_VESICLE_EXOCYTOSIS	-2.785	0.007	0.005
GO_NEURON_TO_NEURON_SYNAPSE	-2.781	0.012	0.009
GO_GLUTAMATERGIC_SYNAPSE	-2.775	0.012	0.009
GO_NEUROTRANSMITTER_SECRETION	-2.770	0.007	0.005

NES: normalized enrichment score; P.adjust: adjusted P value; FDR: false discovery rate. Gene sets are deemed significant when their adjust P-value and FDR q-value < 0.05

ISSN: 1471-2407