Fig. 5

LILRB1 functional annotation in glioma. According to GSEA results, the top five KEGG pathways for the LILRB1^high include the toll-like receptor signaling pathway, B cell receptor signaling pathway, chemokine signaling pathway, JAK/STAT signaling pathway and NOD-like receptor signaling pathway. Calcium signaling pathway, cardiac muscle contraction, neuroactive ligand receptor interaction and long-term potentiation are the four KEGG pathways in LILRB1^low (A). GSEA findings showing varying levels of GO term enrichment in relation to LILRB1 expression. Top five GO keywords for LILRB1^high-macrophage activation, regulation of dendritic cell differentiation, neutrophil chemotaxis, regulation of mononuclear cell migration and regulation of leukocyte proliferation. Top five GO keywords for LILRB1^low- neurotransmitter transport, synaptic vesicle exocytosis, neuron to neuron synapse, glutamatergic synapse, neurotransmitter secretion (B). Based on FDR value, adjusted P value and NES, GSEA generated all of its results