Table 6 Estimated pharmacodynamic parameters after fitting the radiation and radiosensitizing model to simulate data with artificially lowered variance for study 1 (only dose groups for \(R{s}_{2}\) were used)
From: Model-based assessment of combination therapies – ranking of radiosensitizing agents in oncology
Parameter | Population Median (RSE%) | Between-subject variabilitya (RSE%) | Description |
|---|---|---|---|
\({k}_{g}\)[1/day] | 0.45 (3.88) | - | Natural growth rate |
\({k}_{k}\)[1/day] | 0.3 (5.5) | - | Natural kill rate |
\(\alpha\)[1/Gy] | 0.07 (4) | 10 (8) | Linear radiation parameter |
\({\gamma }_{1}\)[1/Gy] | 0.04 (4) | 10 (2) | Growth rate inhibition parameter |
\({V}_{\mathrm{0,1}}\)[mm3] | 26 (5) | 39(14) | The initial volume of proliferating cells |
\({a}_{R{s}_{2}}\)[\(\mathrm{mL}/\mathrm{\mu g}\)] | 0.13 (16) | - | Stimulation of short-term effect |
\({b}_{R{s}_{2}}\)[\(\mathrm{mL}/\mathrm{\mu g}\)] | 0.3 (15) | - | Stimulation of long-term effect |
\({\sigma }_{prop}\)[%] | 0.23 | - | Proportional error |
\({\sigma }_{add}\)[mm3] | 8.7 | - | Additive error |