Table 2 Observed average maximum concentration for each treatment group
From: Model-based assessment of combination therapies – ranking of radiosensitizing agents in oncology
Test Compound | Dose [mg/kg] | \({C}_{max}\)(SD) [\(\mathrm{\mu g}/\mathrm{mL}\)] |
|---|---|---|
Study 1 | ||
\(R{s}_{1}\) | 100 | 1 (0.5) |
\(R{s}_{2}\) | 25 | 2 (0.2) |
\(R{s}_{2}\) | 100 | 5 (1.2) |
\(R{s}_{3}\) | 20 | 7 (2.2) |
Study 2 | ||
\(R{s}_{1}\) | 10 | 1 (0.4) |
\(R{s}_{1}\) | 50 | 2 (0.5) |
\(R{s}_{1}\) | 200 | 9 (2.9) |
Study 3 | ||
\(R{s}_{1}\) | 25 | 5 (1.6) |
\(R{s}_{1}\) | 50 | 6 (4) |
\(R{s}_{1}\) | 100 | 7 (2.4) |