Table 1 The study number, sample size, duration, treatment groups, and PK sampling times for each of the three xenograft studies used in this paper
From: Model-based assessment of combination therapies – ranking of radiosensitizing agents in oncology
Study | Sample sizea | Duration of treatment | Treatment Groups (listed treatment applied daily for 5 days a week) | PK sampling timesb |
|---|---|---|---|---|
1 | 9 | 6 weeks | Vehicle, 2 Gy Radiation 100 mg/kg \(R{s}_{1}\)+ 2 Gy Radiation 25 mg/kg and 100 mg/kg \(R{s}_{2}\)+ 2 Gy Radiation 20 mg/kg \(R{s}_{3}\)+ 2 Gy Radiation | 2, 4, and 6 h |
2 | 10 | 1 week | Vehicle, 2 Gy Radiation 10, 50 and 200 mg/kg \(R{s}_{1}\) | 0.5, 2, 4, 6, and 24 h |
3 | 10 | 6 weeks | 2 Gy Radiation 25, 50 and 100 mg/kg \(R{s}_{1}\) + 2 Gy Radiation | 2, 4, and 6 h |