Fig. 5
From: Model-based assessment of combination therapies – ranking of radiosensitizing agents in oncology
TSE curves where the total radiation dose is plotted against the concentration of radiosensitizer. Exposure pairs on the curves are predicted to result in tumor stasis for the given population percentile. a Median TSE predictions using the simulation-based method (blue) and the analytical long-term method (yellow). b 80%, 90%, and 95% percentile predictions using the simulation-based TSE. The three black markers in both subfigures represent the exposure combinations of three treatment groups in study 3. The corresponding number of eradicated tumors observed for different exposure combinations is shown in the legend