Fig. 3

Ferroptosis regulators indicated the prognosis values in GBM. (A) Forest plot showing the result of univariate Cox-regression analysis for correlation between the ferroptosis regulators and the overall survival. (B) Kaplan-Meier curves of GBM samples stratified by the protein abundances of five risk ferroptosis regulators with log-rank test P-value provided, respectively. To determine the protein abundance groups, we divided the corresponding protein expression levels into quartiles. Samples with expression levels falling below the first quartile were assigned to the low abundance group, and those above the three-quarters loci were assigned to the high abundance group. (C) Violin plot showing the difference in risk score between high-risk and low-risk groups. (D) Kaplan-Meier curve of GBM samples stratified by the risk groups with log-rank test P-value provided. (E) Violin plots showing the differences in protein abundances of five risk ferroptosis regulators between high-risk and low-risk groups. (F) Validation of risk ferroptosis regulators in internal and external RNA-seq cohorts. P-values were calculated by Mann–Whitney U test (C, E)