Fig. 1

Overview of ferroptosis regulators in human GBM. (A) Unsupervised principal components analysis (PCA) of protein levels of ferroptosis regulators. (B) Correlations mRNA and protein levels of ferroptosis regulators. The top 10 ferroptosis regulators were labeled. (C) Heatmap showing protein abundances of ferroptosis regulators (|log2FC| > 1 and adjusted P-value < 0.01) between GBM tumor tissues and normal brain tissues. (D) Differentially expressed ferroptosis regulators in KEGG ferroptosis pathway. Pathway visualization using the R package “Pathview”