Fig. 6
RNA polymerase II in DDB2 transactivation. (A) The plot described the recruitment of phosphorylated serine 5 residue of RNAPII-CTD on DDB2 gene promoter in unirradiated and irradiated (UVC 5 J/m2) Vector and PTEN-FL cells at four hours post-irradiation by ChIP assay. Values were normalized to input and expressed as median and 95% CI of three independent biological replicates. A two-way ANOVA test was performed to compare multiple groups. * P < 0.05, ** P < 0.01, **** P < 0.0001, ns, not significant. (B) A model depicted a probable mechanism and consequence of high DDB2 expression in PTEN-null EC. Women in blue represented live patients; women in red represented deceased patients