Fig. 1

DDR genes in EC. (A) Analysis of differential expression of DDR genes based on PTEN genetic alteration in TCGA-UCEC [7]. The list of DDR genes curated elsewhere [20] was previously obtained from the PAN-cancer TCGA study. The volcano plot presented the statistical significance and magnitude of change of DDR genes as a ratio of PTEN-altered expression values to unaltered expression values. The green, red, and gray dots, respectively, represent genes that were significantly downregulated, significantly upregulated, and not significant. (B) The scatter plot depicted a correlation between PTEN and DDB2 mRNA expression in UCEC. The correlation plot was generated by the cBioPortal algorithm. (C) The scatter plot illustrated a correlation between PTEN protein expression and DDB2 mRNA expression in 23 endometrial cancer cell lines. Data were obtained from CCLE in DepMap portal and analyzed using Plotly Chart Studio. The variable color scale represented the reverse-phase protein array (RPPA) signal of PTEN, and the area of each circle represented DDB2 mRNA expression in the individual cell lines. All statistical analyses of the datasets were obtained directly from the respective portals