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Table 4 Univariable and multivariable Cox regression analyses of the OS of patients with UTIs

From: Urinary tract infection after radiation therapy or radical prostatectomy on the prognosis of patients with prostate cancer: a population-based study

Variables

Number of patients at risk

No. (%)

Person-years

Incidence rate (per 1,000 person-years)

Univariable

Multivariable

HR (95% CI)

p-values

HR (95% CI)

p-values

Treatment

 - Radiation

930

237 (25.5)

5875.6

40.3

1 (reference)

 

1 (reference)

 

 - \(<\) 20 m Robot-assisted

2,145

130 (6.1)

3115.6

41.7

0.48 (0.38 – 0.62)

< 0.001

0.68 (0.53 – 0.88)

0.004

 - \(\ge\) 20 m Robot-assisted

1,597

123 (7.7)

4399.0

28.0

0.41 (0.23 – 0.77)

0.006

0.59 (0.32 – 1.09)

0.092

 - \(<\) 20 m Open/laparoscopic

3,243

136 (4.2)

4866.2

27.9

0.33 (0.25 – 0.42)

< 0.001

0.43 (0.33 – 0.55)

< 0.001

 - \(\ge\) 20 m Open/laparoscopic

2,584

249 (9.6)

8517.9

29.2

0.43 (0.24 – 0.76)

0.004

0.57 (0.32—1.02)

0.058

Age Group at PC diagnosis

 - \(<\) 75 y

5,309

606 (11.4)

35549.8

17.0

1 (reference)

 

1 (reference)

 

 - \(\ge\) 75 y

1,009

269 (26.7)

5818.3

46.2

2.73 (2.36 – 3.15)

< 0.001

1.05 (0.86 – 1.29)

0.635

CCI score

 - 0–1

1,201

198 (16.5)

8645.6

22.9

1 (reference)

 

1 (reference)

 

 - 2–3

2,082

248 (11.9)

14061.8

17.6

0.73 (0.61 – 0.88)

0.001

0.75 (0.62 – 0.91)

0.003

 - ≥ 4

3,035

429 (14.1)

18660.7

23.0

0.95 (0.81 – 1.13)

0.584

0.90 (0.75 – 1.09)

0.283

Diabetes

 - NO

3,666

475 (13.0)

23589.1

20.1

1 (reference)

 

1 (reference)

 

 - YES

2,652

400 (15.1)

17779.0

22.5

1.14 (1.00 – 1.30)

0.050

1.045 (0.90 – 1.20)

0.560

Renal disease

 - NO

5,826

779 (13.4)

37978.1

20.5

1 (reference)

 

1 (reference)

 

 - YES

492

96 (19.5)

3390.0

28.3

1.45 (1.17 – 1.79)

< 0.001

1.16 (0.93 – 1.44)

0.187

Age at UTI diagnosis

6,318

875 (13.9)

41368.1

21.2

1.10 (1.09 – 1.11)

< 0.001

1.08 (1.07 – 1.10)

< 0.001

UTI within 3 months after treatment

 - NO

5,054

731 (14.5)

35126.9

20.8

1 (reference)

 

1 (reference)

 

 - YES

1,264

144 (11.4)

6241.2

23.1

0.57 (0.48 – 0.69)

< 0.001

0.78 (0.64 – 0.94)

0.011

UTI type

 - LOWER

5,254

603 (11.5)

31022.0

19.4

1 (reference)

 

1 (reference)

 

 - UPPER

1,064

272 (25.6)

10346.1

26.3

1.73 (1.50 – 2.00)

< 0.001

1.23 (1.05 – 1.44)

0.010

Hospitalization at UTI diagnosis

 - NO

5,574

704 (12.6)

36617.9

19.2

1 (reference)

 

1 (reference)

 

 - YES

744

171 (23.0)

4750.2

36.0

2.29 (1.93 – 2.70)

< 0.001

1.91 (1.59 – 2.30)

< 0.001

Sepsis from UTI

 - NO

6,289

865 (13.8)

41232.8

21.0

1 (reference)

 

1 (reference)

 

 - YES

29

10 (34.5)

135.3

73.9

2.8 (1.50 – 5.23)

< 0.001

2.63 (1.39 – 4.96)

0.003

  1. The model was adjusted for age at PC diagnosis, period of PC diagnosis, CCI score, diabetes, renal disease, age at UTI diagnosis, UTI within 3 months after treatment, UTI type, hospitalization, and sepsis from UTI
  2. Abbreviations: OS Overall survival, PC Prostate Cancer, UTI urinary tract infection, ADT Androgen deprivation therapy, CCI Charlson Comorbidity Index
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BMC Cancer

ISSN: 1471-2407

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