Table 4 Reasons for treatment adjustment

Discontinuation of regorafenib

21

Reason for discontinuation (includes duplication)

 Progression of primary disease

14

 Hepatic dysfunction

3

 Hypertension

2

 Nephropathy/proteinuria

2

 High fever

2

 Erythema multiforme

2

 Diarrhea

1

Interruption of regorafenib

22

Reasons for interruption (includes duplication)

 Hepatic dysfunction

9

 Hypertension

6

 High fever

6

 Nephropathy/proteinuria

4

HFSR

3

 Erythema multiforme

2

 Thrombocytopenia

2

 Diarrhea

1

 Fatigue

1

 Nosebleed

1

Dose reduction of regorafenib

4

Reasons for dose reduction (includes duplication)

 High fever

2

 Hypertension

2

 Nephropathy/proteinuria

1

 Thrombocytopenia

1

 Fatigue

1