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Table 5 Lymph node metastasis (LNM) and recurrence of pT1b ESCC patients with VIa /LIb in different locations (intratumoral or peritumoral region)

From: Prognostic significance of lymphovascular invasion in patients with pT1b esophageal squamous cell carcinoma

Type of VI/LI

Total

LNM (%)

P

Recurrence (%)

P

E-VIc + 

109

35 (32.1)

 

53 (48.6)

 

Intratumoral region alone

47

14 (29.8)

0.129

22 (46.8)

0.538

Peritumoral region alone

22

11 (50.0)

13 (59.1)

Both of two

40

10 (25.0)

18 (45.0)

CD31-VId + 

40

15 (37.5)

 

20 (50.0)

 

Intratumoral region alone

8

4 (50.0)

0.357

5 (62.5)

0.311

Peritumoral region alone

22

9 (40.9)

12 (54.5)

Both of two

10

2 (20.0)

3 (30.0)

D2-40-LIe + 

78

27 (34.6)

 

38 (48.7)

 

Intratumoral region alone

11

1 (9.10)

0.081

9 (81.8)

0.116

Peritumoral region alone

45

16 (35.6)

19 (42.2)

Both of two

22

10 (45.5)

10 (45.5)

  1. aVI vascular invasion
  2. aLI lymphatic vessel invasion
  3. cE-VI vascular invasion detected by elastin staining + CK (AE1/AE3) immunohistochemistry
  4. dCD31-VI vascular invasion detected by CD31 + CK (AE1/AE3) double immunohistochemistry
  5. eD2-40-LI lymphatic vessel invasion detected by D2-40 + CK (AE1/AE3) double immunohistochemistry