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Table 4 Multivariate Cox proportional hazards models for recurrence-free survival (RFS) and overall survival (OS) in 154 pT1b ESCC a patients

From: Prognostic significance of lymphovascular invasion in patients with pT1b esophageal squamous cell carcinoma

Clinicopathological characteristics

RFS

OS

HR

95% CI

P

HR

95% CI

P

Tumor location

 Upper thoracic

2.598

1.447–4.668

0.001

2.419

1.292–4.530

0.006

 Middle thoracic

1

  

1

  

 Lower thoracic

1.305

0.617–2.759

0.486

1.196

0.537–2.663

0.661

E-VI b

 Positive

2.402

1.160–4.974

0.018

2.908

1.288–6.568

0.010

 Negative

1

  

1

  

CD31-VI c

 Positive

2.832

1.594–5.034

 < 0.001

-

-

-

 Negative

1

  

-

-

-

D2-40-LI d

 L0

1

  

-

-

-

 L1

1.327

0.737–2.389

0.345

-

-

-

 L2

4.609

2.273–9.344

 < 0.001

-

-

-

LNM e

 Yes

-

-

-

1.983

1.096–3.587

0.024

 No

-

-

-

1

  
  1. aESCC esophageal squamous cell carcinoma
  2. bE-VI vascular invasion detected by elastin staining + CK (AE1/AE3) immunohistochemistry
  3. cCD31-VI vascular invasion detected by CD31 + CK (AE1/AE3) double immunohistochemistry
  4. dD2-40-LI lymphatic vessel invasion detected by D2-40 + CK (AE1/AE3) double immunohistochemistry. L0, L1, and L2: the count of D2-40-LI was 0, 1–4, and 5 or more
  5. eLNM lymph node metastasis
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BMC Cancer

ISSN: 1471-2407

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