Table 4 Characteristics of patients with variant DPYD genotypes with severe toxicity
DPYD variant | Age (years) | Treatment | FP starting dose (%) | Toxicity |
|---|---|---|---|---|
c.2846A > T het | 60–69 | FOLFIRINOX | 50% | Grade 4 gastrointestinal toxicity after 1 cycle |
c.1601G > A het | 50–59 | FOLFIRINOX | 50% | Grade 3 other toxicity after 8 cycles |
c.1601G > A het | 60–69 | CAPOX | 75% | Grade 3 gastrointestinal toxicity after 2 cycles |
c.1905 + 1G > A het | 40–49 | FOLFIRINOX | 50% | Grade 4 haematological toxicity at 8 cycles |