Table 1 Patient baseline characteristics
| Â | DPYD variant N (%) | DPYD wildtype N (%) | Total N (%) |
|---|---|---|---|
Total | 33 (8.9) | 337 (91.1) | 370 (100) |
Median age, years (range) | 62 (30–88) | 65 (28–90) | 64 (28–90) |
Sex | |||
 Male | 21 (63.6) | 217 (64.4) | 238 (64.3) |
 Female | 12 (37.4) | 120 (35.6) | 132 (35.7) |
Tumour | |||
 Colorectal | 23 (69.7) | 186 (55.2) | 209 (56.5) |
 Oesophagogastric | 5 (15.2) | 88 (26.1) | 93 (25.1) |
 Hepatopancreatic biliary | 4 (12.1) | 48 (14.2) | 52 (14.1) |
 Other a | 1 (3.0) | 15 (4.5) | 16 (4.3) |
Ethnicity | |||
 White | 27 (81.8) | 247 (73.1) | 274 (74.1) |
 Asian | 2 (6.1) | 27 (8.0) | 29 (7.8) |
 Black | 0 (0) | 15 (4.4) | 15 (4.1) |
 Other | 4 (12.1) | 26 (7.7) | 30 (8.1) |
 Undisclosed | 0 (0) | 12 (3.6) | 12 (3.2) |
ECOG Performance Status | |||
 0 | 10 (30.3) | 90 (26.6) | 100 (27.0) |
 1 | 21 (63.6) | 233 (68.9) | 254 (68.6) |
 2 | 2 (6.1) | 14 (4.1) | 16 (4.3) |