Table 1 Association of Osteopontin splice variants with various cancers according to published reports. Only cancers with multiple evaluable reports are listed. The left column displays the cancer type under study, the three blocks have the numbers for Osteopontin-a (OPN-a), Osteopontin-b (OPN-b), and Osteopontin-c (OPN-c). Results in bold are considered significant at the 5% probability of error level. studies = number of original reports underlying the analysis, n = number of patients analyzed, χ² = result of the χ² test, p-value = significance according to the χ² test, “normal” indicates healthy tissue. A warning occurred when χ² was below 5. In all of those cases, the p-value according to Fisher’s exact test corroborated the results

cancer

studies

n

category

low

high

χ²

p-value

Fisher p-value

studies

n

category

low

high

χ²

p-value

Fisher p-value

studies

n

category

low

high

χ²

p-value

Fisher p-value

breast

3

354

cancer

106

108

0.25305

0.6149

0.5871

3

354

cancer

109

105

1.3646

0.2427

0.2307

4

479

cancer

91

179

90.994

 < 2.2e-16

 < 2.2e-16

normal

74

66

normal

81

59

normal

163

46

lung

2

146

cancer

24

45

69.565

 < 2.2e-16

 < 2.2e-16

2

146

cancer

11

58

103.9

 < 2.2e-16

 < 2.2e-16

2

301

cancer

48

89

43.947

3.37E-11

1.64E-11

normal

77

0

normal

77

0

normal

121

43

liver

2

21

cancer

0

11

4.7256

0.02972

0.01238

2

21

cancer

0

11

4.7256

0.02972

0.01238

2

21

cancer

8

3

0.38595

0.5344

0.387

normal

5

5

normal

5

5

normal

5

5

pancreatic

2

127

cancer

7

40

13.261

0.0002709

0.000116

2

127

cancer

19

28

2.3665

0.124

0.09988

2

127

cancer

33

14

0.1661

0.6836

0.5655

normal

39

41

normal

45

35

normal

52

28

glioma

2

168

cancer

77

82

1.8784

0.1705

0.1678

2

168

cancer

75

84

2.0862

0.1486

0.0934

2

168

cancer

77

82

0.52134

0.4703

0.3259

normal

7

2

normal

7

2

normal

6

3

all

17

1844

cancer

503

562

18.626

1.59E-05

1.41E-05

17

1844

cancer

490

575

47.786

4.754E-12

3.474E-12

19

2274

cancer

566

743

170.35

 < 2.2e-16

 < 2.2e-16

normal

448

331

normal

486

293

normal

684

281