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Table 4 Hazard ratio of tumor survival for all 661 patients with breast cancer according to the mtDNA copy number in different subgroups stratified by clinical parameters

From: High leukocyte mitochondrial DNA copy number contributes to poor prognosis in breast cancer patients

Variables

 

5-Year iDFS

  

5-Year DDFS

  

5-Year BCSS

  

5-Year OS

  
  

Ajusted HR*(95%CI)

P

P for interaction

Ajusted HR*(95%CI)

P

P for interaction

Ajusted HR*(95%CI)

P

P for interaction

Ajusted HR*(95%CI)

P

P for interaction

Age

   

0.266

  

0.275

  

0.204

  

0.238

 ≤ 40

207

1.847 (1.047–3.259)

0.034

 

1.810 (0.982–3.336)

0.057

 

2.096 (0.946–4.645)

0.068

 

2.096 (0.946–4.645)

0.068

 

 >40

454

1.262 (0.853–1.869)

0.244

 

1.178 (0.784–1.769)

0.430

 

1.204 (0.738–1.964)

0.457

 

1.248 (0.767–2.031)

0.373

 

HR

   

0.687

  

0.334

  

0.028

  

0.022

 Negative

235

1.390 (0.847–2.282)

0.193

 

1.177 (0.714–1.939)

0.522

 

0.988 (0.586–1.667)

0.964

 

0.988 (0.586–1.665)

0.963

 

 Positive

426

1.473 (0.962–2.256)

0.075

 

1.520 (0.958–2.411)

0.075

 

2.340 (1.163–4.708)

0.017

 

2.446 (1.218–4.913)

0.011

 

HER2

   

0.501

  

0.232

  

0.640

  

0.604

 Negative

467

1.551 (1.018–2.362)

0.041

 

1.573 (0.997–2.482)

0.051

 

1.497 (0.860–2.606)

0.153

 

1.535 (0.884–2.667)

0.128

 

 Positive

194

1.336 (0.808–2.208)

0.258

 

1.135 (0.684–1.884)

0.623

 

1.287 (0.684–2.420)

0.434

 

1.318 (0.702–2.475)

0.390

 

Grade

   

0.795

  

0.828

  

0.709

  

0.701

 I + II

500

1.374 (0.954–1.981)

0.088

 

1.355 (0.920–1.994)

0.124

 

1.427 (0.887–2.295)

0.142

 

1.467 (0.914–2.356)

0.112

 

 III

161

1.596 (0.793–3.210)

0.190

 

1.290 (0.638–2.610)

0.478

 

1.347 (0.567-3.200)

0.499

 

1.375 (0.580–3.262)

0.469

 

Tumor sizes

   

0.347

  

0.329

  

0.942

  

0.975

 ≤ 2

211

2.053 (0.997–4.230)

0.051

 

2.042 (0.946–4.405)

0.068

 

1.519 (0.657–3.508)

0.328

 

1.519 (0.657–3.508)

0.328

 

 >2

450

1.302 (0.907–1.868)

0.152

 

1.229 (0.843–1.793)

0.283

 

1.430 (0.885–2.312)

0.144

 

1.479 (0.916–2.387)

0.109

 

Nodal status

   

0.170

  

0.240

  

0.208

  

0.290

 Negative

255

0.941 (0.502–1.767)

0.851

 

0.882 (0.442–1.759)

0.721

 

0.766 (0.310–1.892)

0.564

 

0.864 (0.354–2.107)

0.747

 

 Positive

406

1.603 (1.101–2.334)

0.013

 

1.499 (1.016–2.211)

0.041

 

1.577 (0.986–2.522)

0.057

 

1.597 (0.999–2.553)

0.050

 
  1. Abbreviations: iDFS, invasive disease-free survival; DDFS, distant disease-free survival; BCSS, breast cancer special survival; OS, overall survival; CI, confidence interval; mtDNA, mitochondrial DNA; aHR: adjusted hazard ratio
  2. * adjusted for age at diagnosis, tumor size, lymph node involvement, grade, hormone receptor status, and HER2 status, except for the interaction factor
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BMC Cancer

ISSN: 1471-2407

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