High leukocyte mitochondrial DNA copy number contributes to poor prognosis in breast cancer patients

BMC Cancer

Table 3 Results of Cox model on breast cancer risk for the quintile 2 to 5 of mtDNA copy number versus quintile 1 (as reference category)

	5-Year iDFS		5-Year DDFS		5-Year BCSS		5-Year OS
	Quintile 2–5 versus quintile 1		Quintile 2–5 versus quintile 1		Quintile 2–5 versus quintile 1		Quintile 2–5 versus quintile 1
Adjust model^*	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P
Model1	1.476 (1.073–2.031)	0.016	1.418 (1.015–1.981)	0.040	1.477 (0.980–2.226)	0.062	1.522 (1.011–2.291)	0.044
Model2	1.431 (1.040–1.970)	0.028	1.355 (0.970–1.894)	0.075	1.378 (0.914–2.078)	0.126	1.420 (0.942–2.140)	0.094
Model3	1.433 (1.038–1.978)	0.028	1.355 (0.966-1.900)	0.078	1.406 (0.928–2.130)	0.108	1.440 (0.951–2.179)	0.084

Abbreviations: iDFS, invasive disease-free survival; DDFS, distant disease-free survival; BCSS, breast cancer special survival; OS, overall survival; CI, confidence interval; mtDNA, mitochondrial DNA; HRs: hazard ratios
^* Model 1: adjusted for age at diagnosis; Model 2: same as model 1, plus hormone receptor status. HER2 status; Model 3: same as model 2, plus tumor size, Lymph node involvement, grade

ISSN: 1471-2407