High leukocyte mitochondrial DNA copy number contributes to poor prognosis in breast cancer patients

BMC Cancer

Table 1 Patients’ clinicopathological characteristics and clinical outcome

Variables	Patients	5-Year iDFS		5-Year DDFS		5-Year BCSS		5-Year OS
	N = 661	Events	LogRank P	Events	LogRank P	Events	LogRank P	Events	LogRank P
Age at diagnosis			0.136		0.331		0.754		0.934
≤ 40	207	97		86		56		56
>40	454	182		168		120		124
Tumor size(cm)			<0.001		<0.001		<0.001		<0.001
≤ 2	211	55		48		34		34
>2	450	224		206		142		146
Nodal status			<0.001		<0.001		<0.001		<0.001
Negative	255	66		55		30		33
Positive	406	213		199		146		147
Clinical stage			<0.001		<0.001		<0.001		<0.001
I	127	21		17		12		12
II + III	534	258		237		164		168
Grade			<0.001		<0.001		<0.001		<0.001
I + II	500	190		172		118		121
III	161	89		82		58		59
HR			<0.001		<0.001		<0.001		<0.001
Negative	235	129		121		99		100
Positive	426	150		133		77		80
HER2			<0.001		<0.001		<0.001		<0.001
Negative	467	170		152		103		106
Positive	194	109		102		73		74
Subtype			<0.001		<0.001		<0.001		<0.001
LuminalA	123	18		17		8		8
Luminal B	303	132		116		69		72
HER2+	101	64		59		48		48
Triple negative	134	65		62		51		52

Abbreviations: iDFS, invasive disease-free survival; DDFS, distant disease-free survival; BCSS, breast cancer special survival; OS, overall survival; HR, Hormone receptor; HER2, human epidermal growth factor-2

ISSN: 1471-2407